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49ers vs. Bills ATS Picks

NFL Week 6 NFL Betting Odds

The Buffalo Bills will have an excellent shot of pushing their win streak to four in a row in Week 6 when Rex Ryan’s troops return home to host a San Francisco 49ers outfit that’s failed to win or cover each of its first two road games. The Niners have dropped four straight while the Bills have posted three straight wins since stinking up the joint on Thursday Night Football against the Jets. Something will have to give in this one.

San Francisco 49ers vs. Buffalo Bills
Date and Time: Sunday, October 16, 2016, 1 p.m. ET
Location: New Era Field, Orchard Park, NY
Week 6 NFL Odds at Bills -8.5, 44
49ers vs. Bills TV Coverage: FOX

With Blaine Gabbert at the helm of the offense, the Niners averaged just 291.4 total yards and 171 passing yards per game. Each stat has the Niners ranked No. 31 out of 32 teams as we head into the sixth week of the regular season. While he added a bit to San Fran’s rushing attack with 172 yards and a pair of touchdowns on 39 overall carries, Gabbert was just demoted for the controversial Colin Kaepernick who will make his 2016 debut against the Bills.

In their two road games played to date, San Francisco failed to cover as double digit underdogs to Carolina (46-27) and Seattle (37-18). The team has been much more competitive at home where it pounded Los Angeles, hung with the Cowboys through three quarters, and played even with the Cardinals before getting outscored 26-14 in the second half. San Fran has been a bit more competitive under the new regime, but still has a ways to go before it’s actually taken seriously.

What a difference three weeks make! Buffalo looked listless in a season opening 13-7 loss at Baltimore. It followed that tough defeat up with a terrible 37-31 loss to the Jets in a game that saw Matt Forte turn back the clock to his earlier playing days with 100 yards rushing and three touchdowns.

The Bills have looked like a completely different team since with the offense posting an average of 26.3 points per game, and most importantly, the defense stepping up by shutting out the Patriots in Foxborough and allowing less than 20 points to Arizona and Los Angeles. The Bills now own the No. 5 ranked defensive yard per point average in the league (20.4), and will be looking to improve upon that mark in Kaepernick’s 2016 debut.

Player to Watch

LeSean McCoy – The Bills bell cow has been instrumental in helping Buffalo’s offense flourish over the course of its current winning streak. After being held in check the first two weeks, he exploded in Week 3 against the Cardinals for 110 yards and two touchdowns. Though he didn’t hit pay dirt in Week 4 versus New England, his 19 carries for 70 yards allowed the Bills to dominate the time of possession battle. Then last week, he gouged the Rams for 150 yards on 18 carries.

San Francisco just allowed David Johnson to chew it up and spit it out by rumbling for 157 yards and two touchdowns on a whopping 27 carries. Shady will no doubt be a target for DFS cash game players this week.

49ers vs. Bills Free Picks

A majority of the betting public is going to look at the odds at for this game and scratch their collective heads. San Francisco just lost at home to the same Cardinals squad Buffalo destroyed at home to begin their current win streak. The Bills closed as 5 point underdogs to Arizona while San Francisco closed as 3.5 point underdogs. Buffalo won by 15 points while the Niners fell by 12. It simply doesn’t add up, and that’s why close to 60 percent of the tickets written are backing the home team.

Not this guy! I’m still not sold on Buffalo and believe their defense made the most of advantageous situations the last three weeks. Take the points and look for the Niners to put forth their best showing away from Levi’s Stadium to date.

49ers vs. Bills ATS Pick: 49ers +8.5 at
49ers vs. Bills Score Prediction: Bills 28 – 49ers 27